Immunosuppressive and Stem Cells Essay

Anti-rejection medications have immediate side effects may include gastrointestinal problems, mouth sores, stomach upset. By taking these medications also increase the risk of developing certain tumors and cancers.Diet and Nutrition the person who undergoes pancreatic transplantation should follow a particular diet worked out with dietician or a health care provider.
Stem Cells
It is an alternative for transplantable cells. These stem cells have remarkable capacity to develop into different cell types in the body. It acts as an internal repair system in many tissues. When the division of stem cells occurs, each divided new cell has the capacity to remain as a stem cell or become different type of cell with a more specific function. Such as brain cells, muscle cells, red blood cells.
Embryonic Stem Cells, Induced Pluripotent Stem cells and pancreas derived stem cells be able to distinguish into beta cells. Hepatic stem cells expressing PDX-1(Pancreatic and duodenal homeobox-1) differentiate into cells, and improved Excessive glucose levels in the blood of diabetic mice. Embryonic stem cells are separated from blastocysts, and it can distinguish into ectoderm, endoderm and mesoderm cells. They can also distinguish into insulin producing cells, and these cells are able to secret insulin in response to glucose stimuli and to regularize the glucose levels in blood of diabetic mice when it transferred into diabetes mice. The stem cells production from a pluripotent resource is called as induced pluripotency. For the production of pluripotent stem cells somatic stem cells are reprogrammed under specific conditions such type of cells are called as induced pluripotent stem cells. This cells exhibit rise in the activity which is similar to embryonic stem cells. These are preferred as the best choice for the cell based therapy for diabetes mellitus. For the production of IPSC's fibroblast cells are induced and later these cells are converted into pancreatic cells. The transferring of fibroblast derived cells in to diabetic mouse controlled the blood glucose levels.The transdifferentiation of fibroblasts of a patient into similar to pancreatic cells might render a most straightforward clinical application of reprogrammed cells based treatment without the main concerns of human embryonic stem cells or with human induced pluripotent stem cells. It has become the trend for producing cells resources for cell replacement therapy. This method depends on cellular reprogramming of cells regeneration, cells regeneration will occur from an alternative pancreatic progenitor cells in adult pancreas. A classical example of transdifferentiation in the pancreas is acino ductal transdifferentiation or acino ductal metaplasia. Acinar ductal transdifferentiation is a mechanism by which acinar cells are distinguish into duct cells (Figure ). In addition to this, acinar cells are able to distinguish into adipocytes, hepatocyte like cells, controlled by the microenvironment. -cells have the ability to convert into -cells by utilizing -cell ablation model in zebra fish. Glucagon and glucagon like peptide-1 have a strong effect on to cell transdifferentiation and to cell transdifferentiation is also feasible in the case of opposition.